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myeloid/lymphoid, or mixed lineage, leukemia (MLL) gene, TRX1 gene, trithorax homolog, HRX gene or ALL1 gene
7q
Function:
- gene for zinc-finger protein
Pathology:
- involved in translocations forming fusion products involved in myeloid/lymphoid, or mixed lineage, leukemias
- chromosomal translocation in acute leukemia
- t(11;16)(q23;p13.3) involving CBP & MLL
Related
histone-lysine N-methyltransferase 2A; lysine N-methyltransferase 2A; ALL-1; CXXC-type zinc finger protein 7; myeloid/lymphoid or mixed-lineage leukemia protein 1; trithorax-like protein; zinc finger protein HRX; contains: MLL cleavage product N320; N-terminal cleavage product of 320 kDa; p320; contains: MLL cleavage product C180; C-terminal cleavage product of 180 kD; p180 (KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1)
General
proto-oncogene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: histone-lysine N-methyltransferase 2A
LOCUS: human chromosome-11 Q23
SIZE: entity length = 100 KB
entity length = 21 EXONS
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
OMIM correlations
Entrez Gene 7974
References
OMIM :accession 159555