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acute myeloid leukemia with myelodysplasia-related changes (AML-MRC)

Etiology: - many cases are preceded by a myelodysplastic syndrome (MDS) or a myelodysplastic/myeloproliferative neoplasm Genetics: - most cases of AML-MRC associated with genetic aberrations, particularly -5/del(5q), -7/del(7q), &/or complex karyotypes Management: - cytarabine/daunorubicin (Vyxeos) FDA-approved Aug 2017

Interactions

disease interactions

Related

chromosomal translocation t(8;21)(q22;q22) (AML-M2)

General

acute myeloid leukemia (AML)

References

  1. Vardiman J, Reichard K. Acute Myeloid Leukemia With Myelodysplasia-Related Changes. Am J Clin Pathol. 2015 Jul;144(1):29-43. Review. PMID: 26071460
  2. Bankhead C. FDA Approves Fixed Chemo Combo for AML Subtypes. First approval for treatment- and myelodysplasia-related AML. MedPage Today. August 03, 2017 https://www.medpagetoday.com/HematologyOncology/Leukemia/67045