myelin expression factor 2 (MyEF-2, MST156, MYEF2 KIAA1341)

Function: 1) transcriptional repressor of the myelin basic protein gene 2) binds to the proximal MB1 element 5'-TTGTCC-3' of the myelin basic protein gene promoter 3) binding to MB1 & function are inhibited by PURA Structure: - contains 3 RRM domains (RNA recognition motif domains) Compartment: nucleus Alternative splicing: named isoforms=4

Properties

SIZE: MW = 64 kD entity length = 600 aa COMPARTMENT: cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 100-178 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 233-310 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif glycine-rich region {330-522} RRM 3 {523-599}

Database Correlations

UniProt Q9P2K5 Pfam PF00076

References

UniProt :accession Q9P2K5