myeloid differentiation primary response protein MyD88 (MYD88)

Function: 1) myeloid differentiation (putative) 2) mediator in NF kappa B signaling (putative) 3) increases level of IL-8 transcription (putative) 4) involved in the Toll-like receptor & IL-1 receptor signaling pathway in the innate immune response 5) acts via IRAK1, IRAK2, IRF7 & TRAF6, leading to NF-kappa-B activation, cytokine secretion & the inflammatory response 6) role in IL-18-mediated signaling pathway 7) forms heterodimers with TIRAP 8) binds to TLR2, TLR4, IRAK1, IRAK2 & IRAK4 via their respective TIR domains 9) interacts with IL18R1 (putative) 10) interacts with IL1RL1 11) interacts with IRF7 Structure: - homodimer - the intermediate domain (ID) is required for phosphorylation & activation of IRAK (putative) - contains 1 death domain - contains 1 TIR domain Compartment: cytoplasm Alternative splicing: named isoforms=2 Expression: - ubiquitous - widely expressed except skeletal muscle & brain Pathology: - defects in MYD88 are the cause of MYD88 deficiency - mutations associated with lymphoblastic lymphoma Laboratory: - MYD88 gene p.Leu265Pro mutation

Properties

SIZE: entity length = 296 aa MW = 33 kD COMPARTMENT: cytoplasm MOTIF: death domain NAME: death domain SITE: 54-109 Intermediate domain {110-155} TIR domain {159-296}

Database Correlations

OMIM correlations UniProt Q99836 PFAM correlations Entrez Gene 4615 KEGG correlations

References

UniProt :accession Q99836