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Mycoplasma genitalium
Epidemiology:
- emerging STD
- 21% of young women in on study [2]
- infection (vs colonization) persists for > 12 months
- incidence higher in black women [2]
- no evidence supporting nonsexual routes of transmission in the medical literature [5]
Clinical manifestations:
- urethritis & cervicitis like chlamydia
Laboratory:
- Mycoplasma genitalium DNA
- nucleic acid amplification tests are the only reliable method of diagnosis
- may not be widely available
Management:
1) continue to follow the CDC recommendations for urethritis but .. doxycycline is not reliable, azithromycin once ?
-> azithromycin for 5 days (Z-Pak) 500 mg day 1, then 250 mg QD
2) oxifloxacin (Avelox) 400 mg daily for 10 days is sometimes effective
General
Mycoplasma
Properties
KINGDOM: monera
DIVISION: SCHIZOMYCETES
References
- Prescriber's Letter 14(8): 2007
Mycoplasma genitalium: An Emerging Sexually Transmitted Disease
Detail-Document#: 230802
(subscription needed) http://www.prescribersletter.com
- Sena AC, Lee JY, Schwebke J et al.
A silent epidemic: The prevalence, incidence and persistence
of Mycoplasma genitalium among young, asymptomatic high-risk
women in the United States.
Clin Infect Dis 2018 Jun 18; 67:73-79.
PMID: 29342269
https://academic.oup.com/cid/article-abstract/67/1/73/4802235
- Medical Knowledge Self Assessment Program (MKSAP) 20
American College of Physicians, Philadelphia 2025
- Wikipedia: Mycoplasma genitalium
https://en.wikipedia.org/wiki/Mycoplasma_genitalium
- Hjorth SV, Bjornelius E, Lidbrink P et al
Sequence-based typing of Mycoplasma genitalium reveals sexual transmission.
J Clin Microbiol. 2006 Jun;44(6):2078-83.
PMID: 16757601 PMCID: PMC1489459 Free PMC article.