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nystatin/triamcinolone (Mycolog II, Mycogen II, Tri-Statin II)

Indications: cutaneous candidiasis with pruritus Contraindications: pregnancy-category C safety in lactation ? Dosage: - Apply cream/ointment BID. Cream: Nystatin 100,00 units/gram, triamcinolone 0.1% 15, 30, 60 g. Ointment: Nystatin 100,00 units/gram, triamcinolone 0.1% 15, 30, 60, 120* g. * ref [1] Adverse effects: - not common (1-10%) - dryness, folliculitis, hypertrichosis, acne, hypopigmentation, allergic dermatitis, maceration of the skin, skin atrophy, burning, itching, irritation, secondary infection Mechanism of action: 1) corticosteroid 2) binding of fungal sterols resulting in altered fungus cell wall permeability

General

antibiotic-glucocorticoid combination

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
  2. Drug Information & Medication Formulary, Veterans Affairs, Central California Health Care System, 1st ed., Ravnan et al eds, 1998 - not on National VA formulary
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998

Components

nystatin (Mycostatin, Nilstat, Nystop, Bio-statin) triamcinolone (TAC, Arsitospan, Kenalog, Trivaris)