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Myb-related protein B (B-Myb, MYBL2, BMYB)

Function: - transcription factor - role in regulation of cell survival, proliferation, & differentiation - transactivates expression of the CLU gene - component of the DREAM complex - phosphorylated by cyclin A/CDK2 during S-phase - phosphorylation at Thr-520 is probably involved in transcriptional activity - B-myb expression is required for cells to traverse the G1/S boundary [3] - induction at G1/S boundary is regulated by release from E2F-mediated transcriptional repression Structure: contains 3 HTH myb-type DNA-binding domains Compartment: nucleus Expression: ubiquitously expressed Note: short 1/2 life

Related

B-myb proto-oncogene

General

myb proto-oncogene protein phosphoprotein

Properties

SIZE: entity length = 700 aa MW = 79 kD COMPARTMENT: cell nucleus MOTIF: HTH myb-type 1 {26-77} MOTIF: DNA-binding motif SITE: 54-77 HTH myb-type 2 {78-133} MOTIF: DNA-binding motif SITE: 106-129 HTH myb-type 3 {134-184} MOTIF: DNA-binding motif SITE: 157-180 Thr phosphorylation site {T266} Ser phosphorylation site {S393} nuclear translocation signal {411-417} Thr phosphorylation site {T440} Thr phosphorylation site {T444} Thr phosphorylation site {T487} Thr phosphorylation site {T494} Thr phosphorylation site {T520} nuclear translocation signal {564-584} MOTIF: Ser phosphorylation site {S577}

Database Correlations

OMIM 601415 UniProt P10244 PFAM correlations Entrez Gene 4605 Kegg hsa:4605

References

  1. Arsura et al Dissociation between p93B-myb and p75c-myb expression during the proliferation and differentiation of human myeloid cell lines. Blood 83:1778 1994 PMID: 8142646
  2. Lam EW et al HPV16E7 oncoprotein deregulates B-myb expression: correlation with targeting of p107/E2F complexes. EMBO J 13:871 1994 PMID: 8112300
  3. Lin D et al Constitutive expression of B-myb can bypass p53-induced Waf1/ Cip1-mediated G1 arrest. PNAS 91:10079 1994 PMID:7937841
  4. Nakagoshi H et al Functional domains in the human B-myb gene product J Biol Chem 268:14161 1993 PMID: 8314782
  5. Entrez Gene :accession 4605
  6. UniProt :accession P10244

Component-of

DREAM complex (LINC complex)