Myb-binding protein 1A (MYBBP1A, P160)

Function: 1) may activate or repress transcription via interactions with sequence specific DNA-binding proteins 2) transcirptional repression may be mediated (at least in part) by histone deacetylase (HDAC) 3) binds to & represses JUN & MYB via the leucine zipper regions present in these proteins 4) binds to & represses PPARGC1A - interaction is abrogated when PPARGC1A is phosphorylated by MAPK1/ERK 5) binds to & stimulates transcription by AHR 6) binds to KPNA2 Compartment: - cytoplasm, nucleus, nucleolus - shuttles between the nucleus & cytoplasm - nuclear import may be mediated by KPNA2 - nuclear export appears to depend partially on XPO1/CRM1 - predominantly nucleolar Alternative splicing: named isoforms=2

Properties

SIZE: MW = 149 kD entity length = 1328 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: interaction with MYB {1-582} MOTIF: Ser phosphorylation site {S11} nuclear export signal {240-258} nuclear export signal {263-281} glutamate-rich region {720-784} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S775} required for nuclear & nucleolar localization {1151-1328} MOTIF: Ser phosphorylation site {S1159} Ser phosphorylation site {S1163} Ser phosphorylation site {S1241} Ser phosphorylation site {S1267} Ser phosphorylation site {S1290} Ser phosphorylation site {S1308} Ser phosphorylation site {S1314}

Database Correlations

OMIM 604885 UniProt Q9BQG0 Pfam PF04931

References

UniProt :accession Q9BQG0