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pyrophosphomevalonate decarboxylase (diphosphomevalonate decarboxylase, mevalonate pyrophosphate decarboxylase, mevalonate [diphospho]decarboxylase, MVD MPD)
Function:
- performs 1st committed step in the biosynthesis of isoprenes
- cholesterol biosynthesis
ATP + (R)-5-diphosphomevalonate
ADP + phosphate + isopentenyl diphosphate + CO2
Structure:
- homodimer
- belongs to the diphosphomevalonate decarboxylase family
Expression:
- expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney & placenta
Pathology:
- mutations associated with linear porokeratosis
Interactions
molecular events
Related
cholesterol biosynthesis
pyrophosphomevalonate decarboxylase gene
General
carboxy-lyase or decarboxylase
phosphoprotein
Properties
SIZE: entity length = 400 aa
MW = 43 kD
MOTIF: Ser phosphorylation site {S96}
Database Correlations
OMIM 603236
UniProt P53602
PFAM correlations
Entrez Gene 4597
ENZYME 4.1.1.33
References
- Textbook of Biochemistry with Clinical Correlations,
3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 442
- UniProt :accession P53602