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mucin-19 (MUC-19, MUC19)
Function: may function in ocular mucus homeostasis
Structure:
- contains 1 CTCK (C-terminal cystine knot-like) domain
- contains 2 VWFC domains
- contains 3 VWFD domains
Compartment: secreted (putative)
Alternative splicing: named isoforms=2
Expression:
- expressed corneal epithelial cells, conjunctival goblet & epithelial cells & lacrimal gland cells (at protein level)
- expressed by mucous cells of the submandibular gland & submucosal gland of the trachea
- expressed by middle ear epithelial cells
Pathology:
- down-regulated in Sjoegren syndrome patients (at protein level)
General
mucin
Properties
SIZE: entity length = 6254 aa
MW = 598 kD
MOTIF: VWFD domain {1-97}
VWFD domain {231-439}
VWFD domain {691-900}
Approximate repeats of G-V-T-G-T-T-G-P-S- A {910-5509}
VWFC domain {6029-6095}
VWFC domain {6097-6159}
MOTIF: cysteine residue {C6158}
MODIFICATION: cysteine residue {C6209}
C-terminal cystine knot {6162-6246}
MOTIF: cysteine residue {C6176}
MODIFICATION: cysteine residue {C6223}
cysteine residue {C6185}
MODIFICATION: cysteine residue {C6239}
cysteine residue {C6189}
MODIFICATION: cysteine residue {C6241}
cysteine residue {C6209}
MODIFICATION: cysteine residue {C6158}
cysteine residue {C6223}
MODIFICATION: cysteine residue {C6176}
cysteine residue {C6239}
MODIFICATION: cysteine residue {C6185}
cysteine residue {C6241}
MODIFICATION: cysteine residue {C6189}
Database Correlations
UniProt Q7Z5P9
Entrez Gene 283463
References
- UniProt :accession Q7Z5P9
- mucin database
http://www.medkem.gu.se/mucinbiology/databases/