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mucin-17 (MUC-17, small intestinal mucin-3, MUC-3, MUC17, MUC3)
Function:
- probably plays a role in maintaining homeostasis on mucosal surfaces
- interacts via its C-terminus with PDZK1 & this interaction appears important for proper localization
- probably cleaved within the SEA domain
Structure:
- N-glycosylated, not O-glycosylated
- contains high mannose & complex-type glycans
- contains 1 EGF-like domain
- contains 1 SEA domain
Compartment:
- membrane
- forms containing the complex type glycans localize to the cell surface
- isoform 2: secreted (probable)
Alternative splicing: named isoforms=2
Expression:
- expressed almost exclusively in the intestine
- expression is especially high in both the duodenum & transverse colon
- expressed in mature absorptive cells of the small intestinal villi
- no expression is detected in goblet cells
Pathology:
- highly expressed in pancreatic adenocarcinoma tissue (at protein level)
- expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers
General
mucin
Properties
SIZE: entity length = 4493 aa
MW = 452 kD
MOTIF: signal sequence {1-25}
serine-rich region {84-3836}
MOTIF: serine residue (SEVERAL)
consensus repeat {185-245}
consensus repeat {246-300}
consensus repeat {301-361}
consensus repeat {362-418}
consensus repeat {420-477}
N-glycosylation site {N471}
consensus repeat {479-538}
consensus repeat {539-597}
consensus repeat {598-654}
consensus repeat {656-715}
N-glycosylation site {N696}
consensus repeat {716-774}
consensus repeat {775-831}
consensus repeat {833-892}
consensus repeat {893-951}
N-glycosylation site {N898}
consensus repeat {952-1010}
consensus repeat {1011-1069}
consensus repeat {1070-1121}
consensus repeat {1122-1187}
consensus repeat {1188-1246}
consensus repeat {1247-1305}
consensus repeat {1306-1364}
N-glycosylation site {N1345}
consensus repeat {1365-1423}
consensus repeat {1424-1482}
consensus repeat {1483-1541}
consensus repeat {1542-1600}
consensus repeat {1601-1656}
consensus repeat {1658-1717}
consensus repeat {1718-1776}
consensus repeat {1777-1835}
consensus repeat {1836-1895}
consensus repeat {1896-1951}
consensus repeat {1953-2012}
consensus repeat {2013-2071}
consensus repeat {2072-2127}
N-glycosylation site {N2077}
consensus repeat {2129-2188}
consensus repeat {2189-2247}
N-glycosylation site {N2194}
consensus repeat {2248-2306}
consensus repeat {2307-2365}
consensus repeat {2366-2424}
consensus repeat {2425-2483}
consensus repeat {2484-2540}
consensus repeat {2542-2601}
consensus repeat {2602-2653}
consensus repeat {2654-2719}
consensus repeat {2720-2770}
consensus repeat {2772-2837}
consensus repeat {2838-2896}
consensus repeat {2897-2955}
consensus repeat {2956-3014}
consensus repeat {3015-3073}
consensus repeat {3074-3132}
consensus repeat {3133-3191}
consensus repeat {3192-3247}
consensus repeat {3249-3308}
consensus repeat {3309-3367}
N-glycosylation site {N3344}
consensus repeat {3368-3426}
consensus repeat {3427-3485}
consensus repeat {3486-3544}
consensus repeat {3604-3662}
consensus repeat {3663-3727}
serine-rich region {3975-3980}
MOTIF: serine residue (SEVERAL)
N-glycosylation site {N4116}
EGF domain {4131-4170}
MOTIF: cysteine residue {C4135}
MODIFICATION: cysteine residue {C4147}
cysteine residue {C4140}
MODIFICATION: cysteine residue {C4158}
cysteine residue {C4147}
MODIFICATION: cysteine residue {C4135}
cysteine residue {C4158}
MODIFICATION: cysteine residue {C4140}
cysteine residue {C4160}
MODIFICATION: cysteine residue {C4169}
cysteine residue {C4169}
MODIFICATION: cysteine residue {C4160}
SEA domain {4182-4296}
MOTIF: N-glycosylation site {N4205}
N-glycosylation site {N4236}
peptide motif {4243-4244}
N-glycosylation site {N4267}
N-glycosylation site {N4297}
N-glycosylation site {N4305}
transmembrane domain {4394-4414}
Database Correlations
OMIM 608424
UniProt Q685J3
Pfam PF01390
Entrez Gene 140453
Kegg hsa:1404
References
- UniProt :accession Q685J3
- mucin database
http://www.medkem.gu.se/mucinbiology/databases/