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mu opioid receptor; MOR-1 (OPRM1, MOR1)
Function:
- receptor for beta-endorphin
- selectively sensitive to morphine
- binds enkephalins & endorphins
- inhibits neurotransmitter release by reducing Ca+2 currents & increasing K+ conductance
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Alternative splicing: named isoforms=2
Polymorphism:
- variant Asp-40
a) binds beta-endorphin with 3-fold greater affinity than most common allelic form
b) does not show altered binding affinities for most opioid peptides & alkaloids tested
Interactions
molecular events
General
endorphin receptor or opioid receptor
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 400 aa
MW = 45 kD
COMPARTMENT: synaptic membrane
CELL: neuron
MOTIF: exoplasmic domain {1-66}
MOTIF: N-glycosylation site {N9}
N-glycosylation site {N12}
N-glycosylation site {N33}
N-glycosylation site {N40}
N-glycosylation site {N48}
transmembrane domain {67-96}
cytoplasmic loop {97-105}
transmembrane domain {106-123}
exoplasmic loop {124-145}
MOTIF: cysteine residue {C142}
MODIFICATION: cysteine residue {C219}
transmembrane domain {146-165}
cytoplasmic loop {166-195}
transmembrane domain {196-211}
exoplasmic loop {212-236}
MOTIF: cysteine residue {C219}
MODIFICATION: cysteine residue {C142}
transmembrane domain {237-259}
cytoplasmic loop {260-282}
transmembrane domain {283-305}
exoplasmic loop {306-313}
transmembrane domain {314-330}
cytoplasmic domain {331-400}
MOTIF: cysteine residue {C353}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 600018
UniProt P35372
Pfam PF00001
Kegg hsa:4988
References
- UniProt :accession P35372
- Wikipedia; Note: Mu opioid receptor entry
http://en.wikipedia.org/wiki/Mu_opioid_receptor
- VanDongen AM, Codina J, Olate J, Mattera R, Joho R,
Birnbaumer L, Brown AM.
Newly identified brain potassium channels gated by the guanine
nucleotide binding protein Go.
Science. 1988 Dec 9;242(4884):1433-7.
PMID: 3144040
- Harada H, Ueda H, Katada T, Ui M, Satoh M.
Phosphorylated mu-opioid receptor purified from rat brains
lacks functional coupling with Gi1, a GTP-binding protein
in reconstituted lipid vesicles.
Neurosci Lett. 1990 May 18;113(1):47-9.
PMID: 2164175
- Reisine T, Bell GI.
Molecular biology of opioid receptors.
Trends Neurosci. 1993 Dec;16(12):506-10. Review.
PMID: 7509520