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immunoglobulin mu chain (Ig-mu, IGHM)

Function: - IgM antibodies play an important role in primary defense mechanisms - role in early recognition of external invaders like bacteria & viruses, cellular waste & modified self, as well as in recognition & elimination of precancerous & cancerous lesions. - the membrane-bound form is found in the majority of normal B cells alongside with IgD - membrane-bound IgM induces the phosphorylation of CD79A & CD79B by the Src family of protein tyrosine kinases - membrane-bound IgM is non-covalently associated with heterodimer of CD79A & CD79B - it may cause death of cells by apoptosis - it is also found in soluble form, representing ~30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer - after the antigen binds to the B cell receptor, the secreted form is secreted in large amounts Laboratory: - cytoplasmic Ig mu cells in blood

Related

IgM.heavy chain Ag in tissue

General

immunoglobulin heavy chain

Properties

MOTIF: Ig heavy chain variable region NAME: Ig heavy chain variable region heavy chain constant region-1 MOTIF: cysteine residue {CH1.SITE1} MODIFICATION: cysteine residue {CH1.SITE2} cysteine residue {CH1.SITE2} MODIFICATION: cysteine residue {CH1.SITE1} cysteine residue {C-TO-CH1} MODIFICATION: cysteine residue {C-TO-CL} hinge region MOTIF: cysteine residue {HINGE1} MODIFICATION: cysteine residue {HINGE1} cysteine residue {HINGE2} MODIFICATION: cysteine residue {HINGE2} heavy chain constant region-2 MOTIF: cysteine residue {CH2.SITE1} MODIFICATION: cysteine residue {CH2.SITE2} cysteine residue {CH2.SITE2} MODIFICATION: cysteine residue {CH2.SITE1} heavy chain constant region-3 MOTIF: cysteine residue {CH3.SITE1} MODIFICATION: cysteine residue {CH3.SITE2} cysteine residue {CH3.SITE2} MODIFICATION: cysteine residue {CH3.SITE1} heavy chain constant region-4 MOTIF: cysteine residue {CH4.SITE1} MODIFICATION: cysteine residue {CH4.SITE2} cysteine residue {CH4.SITE2} MODIFICATION: cysteine residue {CH4.SITE1}

Database Correlations

OMIM 147020 SWISS-PROT correlations PFAM correlations

References

  1. Loinc
  2. UniProt :accession P0DOX6
  3. PubMed refs - PMID: 22158414 - PMID: 20176268 - PMID: 3137579 - PMID: 16895553 - PMID: 895553 - PMID: 176268