mitochondrial tumor suppressor 1 (angiotensin-2 type 2 receptor-interacting protein, MTUS1, ATIP, GK1, KIAA1288, MTSG1)

Function: - cooperates with AGTR2 to inhibit ERK2 activation & cell proliferation - may be required for AGTR2 cell surface expression - together with PTPN6, induces UBE2V2 expression upon angiotensin-2 stimulation - interacts with AGTR2 - interacts with PTPN6 Structure: - homodimer - belongs to the MTUS1 family Compartment: - mitochondria, Golgi, cell membrane, nucleus - in neurons, translocates into the nucleus after treatment with angiotensin-2 (putative) Alternative splicing: named isoforms=6 Expression: - ubiquitously expressed (at protein level) - ighly expressed in brain Pathology: - down-regulated in ovarian carcinoma, pancreas carcinoma, colon carcinoma & head & neck squamous cell carcinoma - defects in MTUS1 may be a cause of hepatocellular carcinoma

General

mitochondrial protein phosphoprotein

Properties

SIZE: entity length = 1270 aa MW = 141 kD COMPARTMENT: mitochondria MOTIF: Ser phosphorylation site {S381} Ser phosphorylation site {S443} Ser phosphorylation site {S620} coiled coil {940-1231} Ser phosphorylation site {S1245} Ser phosphorylation site {S1255} Ser phosphorylation site {S1264} Ser phosphorylation site {S1266} Ser phosphorylation site {S1268}

Database Correlations

OMIM 114550 UniProt Q9ULD2

References

UniProt :accession Q9ULD2