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metastasis-associated protein MTA1 (MTA1)
Function:
- may be involved in the regulation of gene expression by covalent modification of histone proteins
- isoform long is a corepressor of estrogen receptor (ER)
- isoform short binds to ER & sequesters it in the cytoplasm & enhances non-genomic responses of ER
- component of the nucleosome-remodeling & histone-deacetylase multiprotein complex (NuRD complex)
- interacts with HDAC1 & ITGB3BP/CENPR
Structure:
- isoform short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif)
- contains 1 BAH domain
- contains 1 ELM2 domain
- contains 1 GATA-type Zn+2 finger
- contains 1 SANT domain
Compartment:
- isoform short: cytoplasm
- isoform long: nucleus
Alternative splicing:
- named isoforms=2; long, short
Expression:
- widely expressed. high expression in brain, ovaries, adrenal glands & virgin mammary glands.
- higher in tumors than in adjacent normal tissue from the same individual
- highly expressed in metastatic cells
General
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 715 aa
MW = 81 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: BAH {1-164}
ELM2 {165-276}
SANT {283-335}
Ser phosphorylation site {S386}
Zn finger GATA-type
SITE: 393-420
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S449}
Thr phosphorylation site {T467}
Ser phosphorylation site {S520}
Ser phosphorylation site {S522}
SH3-binding site
NAME: SH3-binding site
SITE: 545-552
Thr phosphorylation site {T564}
Ser phosphorylation site {S576}
Thr phosphorylation site {T578}
SH3-binding site
NAME: SH3-binding site
SITE: 696-705
MOTIF: proline-rich region
SITE: 697-705
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 603526
UniProt Q13330
PFAM correlations
Entrez Gene 9112
Kegg hsa:9112
References
- UniProt :accession Q13330
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/MTA1ID41443ch14q32.html