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serine/threonine-protein kinase MST4; mammalian STE20-like protein kinase 4; MST-4; Mst3 & SOK1-related kinase; STE20-like kinase MST4; serine/threonine protein kinase MASK (MST4, MASK)
Function:
- may regulate of cell growth
- pro-apoptotic
- interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation
- may also be activated by C- terminal cleavage
Cofactor: Mg+2 (putative)
Structure:
- nhomodimer
- belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
- contains 1 protein kinase domain
Compartment:
- cytoplasm, Golgi membrane
- peripheral membrane protein, cytoplasmic side
- localizes to the Golgi
Alternative splicing: named isoforms=3
General
oligomerizing protein
serine/threonine kinase
Properties
SIZE: entity length = 416 aa
MW = 47 kD
COMPARTMENT: cytoplasm
golgi
STATE: active state
MOTIF: Ser phosphorylation site {S4}
kinase domain
SITE: 24-274
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 30-38
ATP-binding site
NAME: ATP-binding site
SITE: 53-53
aspartate residue {D144}
Thr phosphorylation site {T178}
Ser phosphorylation site {S300}
Ser phosphorylation site {S304}
Ser phosphorylation site {S306}
Ser phosphorylation site {S325}
Thr phosphorylation site {T327}
Database Correlations
OMIM 300547
UniProt Q9P289
Pfam PF00069
Entrez Gene 51765
Kegg hsa:51765
ENZYME 2.7.11.1
References
UniProt :accession Q9P289