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mesothelin; CAK1 antigen; pre-pro-megakaryocyte-potentiating factor; contains: megakaryocyte-potentiating factor; MPF; mesothelin, cleaved form (MSLN, MPF)
Function:
- membrane-anchored forms may play a role in cellular adhesion
- megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro
- proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), & the cleaved form of mesothelin
- both MPF & the cleaved form of mesothelin are N-glycosylated
- interacts with MUC16
Structure:
- belongs to the mesothelin family
Compartment:
- cell membrane; lipid-anchor, GPI-anchor Golgi apparatus
- megakaryocyte-potentiating factor: secreted
- isoform 3: secreted
Alternative splicing:
- named isoforms=4; minor form, major form
Expression:
- expressed in lung
- expressed at low levels in heart, placenta & kidney
- expressed in mesothelial cells
- highly expressed in mesotheliomas, ovarian cancers, & some squamous cell carcinomas (at protein level)
Pathology:
- antibodies against MSLN are detected in patients with mesothelioma & ovarian cancer
- soluble form found in the sera from patients with ovarian carcinoma
Related
mesothelin Ag in tissue
mesothelin related proteins in serum/plasma
General
glypiated protein
protein precursor
Properties
SIZE: entity length = 630 aa
MW = 69 kD
COMPARTMENT: golgi
MOTIF: signal sequence {1-36}
N-glycosylation site {N57}
MPF activity {262-286}
N-glycosylation site {N388}
N-glycosylation site {N496}
N-glycosylation site {N523}
glycosyl phosphatidylinositol [GPI] membrane anchor {N606}
PRECURSOR-FOR: megakaryocyte-potentiating factor
Database Correlations
OMIM 601051
UniProt Q13421
Pfam PF06060
Entrez Gene 10232
References
- UniProt :accession Q13421
- Entrez Gene :accession 10232