MSIN3A histone deacetylase complex

Function: - acts to repress transcription by deacetylation of nucleosomal histones Subunits: - SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, & RBBP7/RbAp46

General

hydrolase molecular complex

Properties

MOTIF: active site SUBUNITS: paired amphipathic helix protein sin3a COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S10} HCFC1 interaction {119-196} MOTIF: paired amphipathic helix {119-189} REST interaction {205-480} MOTIF: proline-rich region SITE: 218-285 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S277} Ser phosphorylation site {S289} paired amphipathic helix {300-383} paired amphipathic helix {456-525} MOTIF: SAP30 interaction {458-525} NCOR1 interaction {523-850} MOTIF: SUDS3/SAP130 interaction {524-659} HDAC1/ARID4B interaction {687-829} Ser phosphorylation site {S832} glutamate-rich region {835-841} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S860} OGT interaction {888-967} MOTIF: coiled coil {903-932} Ser phosphorylation site {S940} Ser phosphorylation site {S1108} Ser phosphorylation site {S1112} histone deacetylase 2 COMPARTMENT: cell nucleus MOTIF: Histone deacetylase {9-322} MOTIF: histidine residue {H142} glycine-rich region {300-303} Ser phosphorylation site {S394} Ser phosphorylation site {S407} Ser phosphorylation site {S422} Ser phosphorylation site {S424} AT-rich interactive domain-containing protein 4B COMPARTMENT: cytoplasm cell nucleus MOTIF: serine-rich region {154-159} MOTIF: serine residue (SEVERAL) glutamate-rich region {268-567} MOTIF: glutamate residue (SEVERAL) ARID {306-398} Antigenic epitope {465-473} Ser phosphorylation site {S710} Ser phosphorylation site {S712} Ser phosphorylation site {S713} Ser phosphorylation site {S717} coiled coil {728-754} Thr phosphorylation site {T1022} Ser phosphorylation site {S1029} serine-rich region {1095-1101} MOTIF: serine residue (SEVERAL) Antigenic epitope {1130-1137} coiled coil {1231-1270} serine-rich region {1271-1303} MOTIF: serine residue (SEVERAL) mortality factor 4-like protein 1 COMPARTMENT: cell nucleus MOTIF: MYST1 interaction {26-62} Sufficient for interaction with SIN3A {133-266} MOTIF: nuclear translocation signal {135-146} RB1-1 interaction {164-230} Sufficient for interaction with PHF12 {188-342} RB1-2 interaction {323-344} histone-binding protein RBBP4 COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl WD repeat {122-155} WD repeat {175-206} WD repeat {225-256} WD repeat {271-302} WD repeat {315-346} WD repeat {372-403} histone-binding protein RBBP7 COMPARTMENT: cell nucleus MOTIF: WD repeat {121-152} WD repeat {174-205} WD repeat {224-255} WD repeat {270-301} WD repeat {314-345} Ser phosphorylation site {S354} WD repeat {371-402} Ser phosphorylation site {S413} Thr phosphorylation site {T416}

References

UniProt :accession Q969N2

Components

AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B, histone deacetylase complex subunit SAP180, 180 kD Sin3-associated polypeptide, Sin3-associated polypeptide p180, Retinoblastoma-binding protein 1-like 1, breast cancer-associated antigen BRCAA1, ARID4B, BRCAA1, RBBP1L1, RBP1L1, SAP180) histone deacetylase 2 (HDAC2) histone-binding protein RBBP4; retinoblastoma-binding protein 4; RBBP-4; retinoblastoma-binding protein p48; chromatin assembly factor 1 subunit C; CAF-1 subunit C; chromatin assembly factor I p48 subunit; CAF-I 48 kD subunit; CAF-I p48; nucleosome-remodeling factor subunit RBAP48 (RBBP4, RbAp48) histone-binding protein RBBP7; retinoblastoma-binding protein 7; RBBP-7; retinoblastoma-binding protein p46; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46 (RBBP7, RBAP46, HAT2) mortality factor 4-like protein 1 (MORF-related gene 15 protein, transcription factor-like protein MRG15, MSL3-1 protein, HSPC008/HSPC061, MORF4L1, MRG15, FWP006, PP368) paired amphipathic helix protein sin3a; murine yeast transcription repressor Sin3 homolog; transcriptional corepressor Sin3a; histone deacetylase complex subunit Sin3a (SIN3A, mSin3A)