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RNA-binding protein Musashi homolog 2 (Musashi-2, MSI2)

Function: 1) RNA binding protein 2) regulates expression of target mRNAs at translation level 3) role in proliferation & maintenance of stem cells in CNS 4) regulates normal hematopoiesis [3] 4) phosphorylated Structure: - contains 2 RRM domains (RNA recognition motif) Compartment: - cytoplasm, associated with polysomes Alternative splicing: named isoforms=3 Expression: - ubiquitous, expressed at low levels - up-regulated in astrocytes after brain injury Pathology: - chromosomal translocations involving MSI2, t(7;17)(p15;q23) with HOXA9 & t(7;17)(q32-34;q23) may contribute to disease progression in chronic myeloid leukemia - overexpressed in myeloid leukemia stem cells [3] - expression levels in human myeloid leukemia directly correlate with decreased survival in patients [3]

General

phosphoprotein RNA-binding protein

Properties

SIZE: MW = 35 kD entity length = 328 aa COMPARTMENT: cytoplasm MOTIF: RNP motif NAME: RNP motif SITE: 21-111 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 110-187 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Breakpoint for translocation to form MSI2/HOXA9 fusion protein {217-218} alanine-rich region {253-260} MOTIF: alanine residue (SEVERAL)

Database Correlations

OMIM 607897 UniProt Q96DH6 Pfam PF00076

References

  1. UniProt :accession Q96DH6
  2. Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/Genes/MSI2ID42893ch17q23.html
  3. Kharas MG et al. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med 2010 Aug; 16:903 PMID: 20616797