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membrane-spanning 4-domains subfamily A member 3 (hematopoietic-specific transmembrane 4 protein, HTm4, CD20 antigen-like protein, MS4A3, CD20L, HTM4)
Function:
1) hematopoietic modulator for the G1-S cell cycle transition
2) modulates phosphorylation of cyclin-dependent kinase 2 (CDK2) via direct binding to cyclin-dependent kinase inhibitor 3 (CDKN3/KAP)
3) interacts with CDKN3
4) interacts with CDKN3-CDK2 complexes through binding to CDKN3 via C-terminal region
Structure:
- belongs to the MS4A family
Compartment:
- intracytoplasmic membrane, cytoplasm, perinuclear region
Alternative splicing: named isoforms=2
Expression:
- expressed specifically in hematopoietic cells & tissues
Related
CD20; B-lymphocyte antigen CD20; membrane-spanning 4-domains subfamily A member 1; B-lymphocyte surface antigen B1; Leu-16; Bp35 (MS4A1)
General
transmembrane 4 protein
Properties
SIZE: MW = 23 kD
entity length = 214 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: cytoplasmic domain {1-49}
transmembrane domain {50-70}
exoplasmic loop {71-81}
transmembrane domain {82-102}
cytoplasmic loop {103-124}
transmembrane domain {125-145}
exoplasmic loop {146-175}
transmembrane domain {176-196}
cytoplasmic domain {197-214}
Database Correlations
OMIM 606498
UniProt Q96HJ5
Pfam PF04103
References
UniProt :accession Q96HJ5