high affinity immunoglobulin epsilon receptor subunit beta; FcERI; IgE Fc receptor subunit beta; Fc epsilon receptor I beta-chain; membrane-spanning 4-domains subfamily A member 2 (MS4A2, APY, FCER1B, IGER)

Function: - beta subunit of IgE receptor Structure: belongs to the MS4A family Compartment: membrane Expression: - found on the surface of mast cells & basophils Polymorphism: - variant Glu-237 has been found to be present in about 5.3% of a 1004 individuals population sample in Australia; it seems to be a risk factor for atopic dermatitis & asthma

General

phosphoprotein protein subunit transmembrane 4 protein

Properties

SIZE: entity length = 244 aa MW = 27 kD COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-59} transmembrane domain {60-79} exoplasmic loop {80-97} transmembrane domain {98-117} cytoplasmic loop {118-130} transmembrane domain {131-150} exoplasmic loop {151-180} transmembrane domain {181-200} cytoplasmic domain {201-244} MOTIF: Tyr phosphorylation site {Y219} Tyr phosphorylation site {Y225} Ser phosphorylation site {S226} Tyr phosphorylation site {Y229}

Database Correlations

OMIM 147138 MORBIDMAP 147138 UniProt Q01362 Pfam PF04103 Kegg hsa:2206

References

UniProt :accession Q01362