mitochondrial 39S ribosomal protein L41 (L41mt, MRP-L41, 39S ribosomal protein L27 homolog, MRP-L27 homolog, BCL2-interacting mitochondrial ribosomal protein L41, proliferation-inducing gene 3 protein, MRPL41, BMRP, PIG3, RPML27)

Function: - component of the mitochondrial 39S ribosomal subunit - role in apoptosis & cell cycle - enhances TP53/p53 stability, thus contributing to TP53/p53- induced apoptosis in response to growth-inhibition - enhances TP53/p53 translocation to mitochondria - able to arrest cell cycle at G1 phase, possibly by stabilizing CDKN1A & CDKN1B (p27Kip1) - interacts with BCL2 Structure: belongs to the ribosomal protein L41 family Compartment: mitochondria Expression: - present in kidney, liver, thymus, testis > brain, spleen (at protein level)

Properties

SIZE: MW = 15 kD entity length = 137 aa COMPARTMENT: mitochondria

References

UniProt :accession Q8IXM3