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MAGUK p55 subfamily member5; membrane protein palmitoylated 5 (MPP5)
Function:
1) biogenesis of tight junctions
2) establishment of cell polarity in epithelial cells
3) modulation of SC6A1-mediated GABA uptake
- stabilizes transporter
4) localization of VIL2 to apical membrane of parietal cells
5) dynamic remodeling of apical cytoskeleton (putative)
6) interacts with the LIN7, CRB3 & MPDZ INADL, PARD6B, SC6A1, VIL2
7) forms a complex with CRB1 & MPP4
8) component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ & PARD3/PAR3
9) heterodimer with MPP1
10) interacts with MPP7
Structure:
- the L27 domain 1 functions in targeting to tight junctions by binding to INADL (putative)
- the PDZ domain binds to the C-terminus of SC6A1
- belongs to the MAGUK family
- contains 1 guanylate kinase-like domain
- contains 2 L27 domains
- contains 1 PDZ domain (DHR domain)
- contains 1 SH3 domain
Compartment:
- cell membrane; peripheral & intracellular membranes
- tight junctions of epithelial cells
- subset of intracellular vesicles
- in retina:
a) outerlimiting membranes
b) apical to the adherens junction
c) colocalizes with CRB1
- Purkinje cell body & axon
Alternative splicing: named isoforms=2
Expression:
- expressed in the retina, cerebellar Purkinje cells
General
MAGUK p55 subfamily
membrane protein
phosphoprotein
Properties
SIZE: entity length = 675 aa
MW = 77 kD
COMPARTMENT: cellular membrane
MOTIF: PARD6B interaction {21-140}
MOTIF: Ser phosphorylation site {S25}
Ser phosphorylation site {S53}
L27 1 {120-177}
L27 2 {179-235}
LIN7C interaction {181-243}
MOTIF: Tyr phosphorylation site {Y243}
PDZ domain
NAME: PDZ domain
SITE: 256-336
src homology 3 [SH3] domain
SITE: 345-417
domain {479-660}
HOMOLOGY: guanylate kinase
Database Correlations
OMIM 606958
UniProt Q8N3R9
PFAM correlations
Entrez Gene 64398
Kegg hsa:64398
References
UniProt :accession Q8N3R9