M phase phosphoprotein 10; U3 small nucleolar ribonucleoprotein protein MPP10 (MPHOSPH10, MPP10)

Function: - component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) - required for the early cleavages during pre-18S ribosomal RNA processing - phosphorylated in M (mitotic) phase - component of a heterotrimeric complex containing IMP3, IMP4 & MPHOSPH10 - interacts with IMP3 & IMP4 Structure: belongs to the MPP10 family Compartment: - nucleus, nucleolus - fibrillar region of nucleolus - after dissolution of the nucleolus in early M phase, becomes associated with chromosomes through metaphase & anaphase - in telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin - reassociation with nucleolus is preceeded by the arrival of fibrillarin

General

M-phase phosphoprotein ribonucleoprotein

Properties

SIZE: MW = 79 kD entity length = 681 aa COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S61} coiled coil {100-129} glutamate residue {134-137} (4) Ser phosphorylation site {S163} coiled coil {196-230} glutamate residue {229-232} (4) coiled coil {275-373} coiled coil {460-481} coiled coil {565-595} coiled coil {639-661} lysine residue {666-670} (5)

Database Correlations

OMIM 605503 UniProt O00566 Pfam PF04006 Entrez Gene 10199 Kegg hsa:10199

References

UniProt :accession O00566