multiple PDZ domain protein (multi PDZ domain protein 1, multi-PDZ-domain protein 1, MPDZ, MUPP1)

Function: 1) interacts with HTR2C & provokes its clustering at the cell surface (putative) 2) component of the NMDAR signaling complex 3) interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4, MPP5 4) interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A & CAMK2B 5) PDZ domain 1 binds NG2 PDZ domain 9 binds F11R PDZ domain 10 binds the C-terminus of CLDN1 & KIT & C-terminal PDZ-binding motif of HTR2C PDZ domain 13 binds CXADR PDZ domain 2 binds CAMK2A & CAMK2B PDZ domains 10 & 13 bind PLEKHA1 & PLEKHA2 PDZ domain 13 binds SYNGAP1 Structure: - contains 1 L27 domain - contains 13 PDZ domain (DHR domains) Compartment: - cell membrane, cytoplasmic side - colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells - enriched in postsynaptic densities (PSD) - localized to punctae on dendrites of hippocampal neurons - colocalizes with synaptic marker DLG4 - localized in Schmidt-Lanterman incisures of myelinating Schwann cells - in the retina, localizes to sub-apical region adjacent to adherens junction complex at the outer limiting membrane - enriched at tight junctions of epithelial cells (CXADR-dependent) Alternative splicing: named isoforms=3 Expression: - expressed in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas Pathology: 1) interacts with the adenovirus type 9 E4-ORF1 protein 2) PDZ domains 7 & 10 bind the Ad9 E4-ORF1 oncoprotein

Properties

SIZE: MW = 219 kD entity length = 2042 aa COMPARTMENT: cytoplasm MOTIF: L27 domain {1-63} PDZ domain NAME: PDZ domain SITE: 137-224 PDZ domain NAME: PDZ domain SITE: 257-337 PDZ domain NAME: PDZ domain SITE: 377-463 PDZ domain NAME: PDZ domain SITE: 553-634 PDZ domain NAME: PDZ domain SITE: 700-786 PDZ domain NAME: PDZ domain SITE: 1008-1089 PDZ domain NAME: PDZ domain SITE: 1151-1243 PDZ domain NAME: PDZ domain SITE: 1350-1433 PDZ domain NAME: PDZ domain SITE: 1483-1564 PDZ domain NAME: PDZ domain SITE: 1629-1712 PDZ domain NAME: PDZ domain SITE: 1725-1807 PDZ domain NAME: PDZ domain SITE: 1834-1920 PDZ domain NAME: PDZ domain SITE: 1959-2042

Database Correlations

OMIM 603785 UniProt O75970 Pfam PF00595

References

UniProt :accession O75970