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mosaicism
- the juxtaposition in any organism of genetically different tissues [1]
- genetic variation between the cells of a single individual [2]
Etiology:
1) lyonization in females (normal)
2) somatic mutation
3) chromosomal aneuploidies [2]
4) chromosomal rearrangements [2]
5) chimerism
6) loss of y chromosome [2]
General
chromosomal aberration
References
- Stedman's Medical Dictionary 27th ed, Williams &
Wilkins, Baltimore, 1999.
- Ledford H
We are all mosaics: vast genetic diversity found between cells in a single person.
Nature. News. Nov 25, 2025
https://www.nature.com/articles/d41586-025-03768-0
- Luquette LJ et al
A comprehensive view of somatic mosaicism by single-cell DNA analysis.
bioRxiv. Nov 3, 2025
https://www.biorxiv.org/content/10.1101/2025.10.31.685648v1