mortality factor 4-like protein 1 (MORF-related gene 15 protein, transcription factor-like protein MRG15, MSL3-1 protein, HSPC008/HSPC061, MORF4L1, MRG15, FWP006, PP368)

Function: - component of the NuA4 histone acetyltransferase complex (HAT) - also component of the MSIN3A complex - MORF4L1 may play role in formation of NuA4 related complexes which lack the HTATIP/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP - MORF4L1 interacts with RB1 & MYST1 - MORF4L1 may also interact with PHF12 & one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors - interacts with the N- terminus of MRFAP1 - found in a complex composed of MORF4L1, MRFAP1 & RB1 Structure: belongs to the MRG family Compartment: nucleus Alternative splicing: named isoforms=2

Properties

SIZE: entity length = 362 aa MW = 41 kD COMPARTMENT: cell nucleus MOTIF: MYST1 interaction {26-62} Sufficient for interaction with SIN3A {133-266} MOTIF: nuclear translocation signal {135-146} RB1-1 interaction {164-230} Sufficient for interaction with PHF12 {188-342} RB1-2 interaction {323-344}

Database Correlations

OMIM 607303 UniProt Q9UBU8 Pfam PF05712

References

UniProt :accession Q9UBU8