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histone acetyltransferase MYST4; MYST-4; histone acetyltransferase MORF; histone acetyltransferase MOZ2; MOZ, YBF2/SAS3, SAS2 & TIP60 protein 4; monocytic leukemia zinc finger protein-related factor (MYST4, KIAA0383, MORF, MOZ2, KAT6B)
Function:
1) positive & negative regulation of transcription; N-terminus is involved in transcriptional activation; C-terminus is involved in transcriptional repression
2) RUNX2-dependent transcriptional activation
3) development of cerebral cortex
4) interacts with RUNX1 & RUNX2
acetyl-CoA + histone CoA + acetylhistone
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- ubiquitously expressed
- highest levels in heart, pancreas, testis, ovary
Pathology:
- chromosomal translocation t(10;16)(q22;p13) with CREBBP associated with acute myeloid leukemia
Related
MYST4 gene (MORF gene)
General
C2H2 type zinc finger protein
histone acetyltransferase
phosphoprotein
Properties
SIZE: entity length = 2073 aa
MW = 231 kD
COMPARTMENT: cell nucleus
MOTIF: H15 {103-176}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 213-272
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 269-320
EFFECTOR-BOUND: Zn+2
Negatively regulates HAT activity {361-717}
MOTIF: serine-rich region {492-533}
MOTIF: serine residue (SEVERAL)
serine-rich region {521-524}
MOTIF: serine residue (SEVERAL)
serine-rich region {599-605}
MOTIF: serine residue (SEVERAL)
active site
SITE: 718-1008
MOTIF: Zn finger C2HC-type
SITE: 749-771
EFFECTOR-BOUND: Zn+2
BRPF1 interaction {752-1008}
cysteine residue {C857}
Ser phosphorylation site {S1027}
Ser phosphorylation site {S1048}
glutamate-rich region {1070-1104}
MOTIF: glutamate residue (SEVERAL)
glutamate-rich region {1204-1207}
MOTIF: glutamate residue (SEVERAL)
breakpoint {1222-1223}
glutamate-rich region {1351-1373}
MOTIF: glutamate residue (SEVERAL)
glutamate-rich region {1409-1417}
MOTIF: glutamate residue (SEVERAL)
RUNX1 and RUNX2 interaction {1560-2073}
MOTIF: serine-rich region {1594-1763}
MOTIF: serine residue (SEVERAL)
Thr phosphorylation site {T1915}
Database Correlations
OMIM 605880
UniProt Q8WYB5
PFAM correlations
Entrez Gene 23522
Kegg hsa:23522
ENZYME 2.3.1.48
References
- OMIM :accession 605880
- UniProt :accession Q8WYB5