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monoclonal immunoglobulin deposition disease (MIDD)
Etiology:
- monoclonal gammopathy of uncertain significance (MGUS)
- multiple myeloma
Pathology:
- disorganized glomerular monoclonal immunoglobulin deposits
- no beta-pleated sheets,
- Congo-red negative staining
- immunoglobulin light chain or immunoglobulin heavy chain deposits
- deposits granular rather than fibrillary on histopathology
Clinical manifestations:
- renal failure, proteinuria +/- nephrotic syndrome
- renal tubular dysfunction
- hypertension
- hepatomegaly (rare)
- cardiomyopathy (rare)
Laboratory:
- urine protein -> proteinuria +/- nephrotic range
- renal biopsy
- glomeruli stain negative with Congo-red
General
deposition disease
paraproteinemia (monoclonal gammopathy)
References
- Medical Knowledge Self Assessment Program (MKSAP) 17,
American College of Physicians, Philadelphia 2015
- Medical Knowledge Self Assessment Program (MKSAP) 19
Board Basics. An Enhancement to MKSAP19.
American College of Physicians, Philadelphia 2022