Search
monoamine oxidase [MAO]-B
Function:
- catalyzes oxidative deamination of biogenic & xenobiotic amines
- role in metabolism of neuroactive & vasoactive amines in the central nervous system & peripheral tissues
- MAOB preferentially degrades benzylamine & phenylethylamine
RCH(2)NH(2) + H2O + O2 RCHO + NH3 + H2O2
Cofactor: FAD
Structure:
- monomer, homodimer or heterodimer (containing two subunits of similar size)
- each subunit contains a covalently bound flavin
- enzymatically active as monomer (putative)
- belongs to the flavin monoamine oxidase family
Compartment: mitochondrial outer membrane, cytoplasmic side
General
monoamine oxidase (MAO)
Properties
SIZE: entity length = 520 aa
MW = 59 kD
COMPARTMENT: mitochondrial outer membrane (GO:0005741)
cytoplasm
MOTIF: lysine-rich region {36-52}
MOTIF: lysine residue (SEVERAL)
catalytic activity {156-156}
catalytic activity {365-365}
catalytic activity {382-382}
transmembrane domain {490-516}
Mitochondrial intermembrane {517-520}
Database Correlations
OMIM 309860
UniProt P27338
Pfam PF01593
Entrez Gene 4129
KEGG correlations
ENZYME 1.4.3.4
References
- UniProt :accession P27338
- SHMPD, The Singapore human mutation and polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=MAOB
- Wikipedia, monoamine oxidase entry
http://en.wikipedia.org/wiki/monoamine_oxidase