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smoothened homolog; SMO; Gx protein (SMO, SMOH)
Function:
- G protein-coupled receptor
- probably associates with patched (PTCH) to transduce hedgehog's signal
- binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened
Structure:
- belongs to the G-protein coupled receptor Fz/smo family
- contains 1 FZ (frizzled) domain
Compartment: membrane
Pathology:
- defects in SMO are involved in basal cell carcinoma
General
glycoprotein
G-protein coupled receptor; serpentine receptor
Properties
SIZE: entity length = 787 aa
MW = 86 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-233}
MOTIF: signal sequence {1-27}
N-glycosylation site {N35}
frizzled domain {65-181}
cysteine residue {C70}
MODIFICATION: cysteine residue {C134}
cysteine residue {C78}
MODIFICATION: cysteine residue {C127}
cysteine residue {C118}
MODIFICATION: cysteine residue {C154}
cysteine residue {C127}
MODIFICATION: cysteine residue {C78}
cysteine residue {C134}
MODIFICATION: cysteine residue {C70}
cysteine residue {C147}
MODIFICATION: cysteine residue {C169}
cysteine residue {C154}
MODIFICATION: cysteine residue {C118}
cysteine residue {C169}
MODIFICATION: cysteine residue {C147}
N-glycosylation site {N188}
transmembrane domain {234-254}
cytoplasmic loop {255-262}
transmembrane domain {263-283}
exoplasmic loop {284-314}
MOTIF: N-glycosylation site {N309}
transmembrane domain {315-335}
cytoplasmic loop {336-358}
transmembrane domain {359-379}
exoplasmic loop {380-402}
transmembrane domain {403-423}
cytoplasmic loop {424-451}
transmembrane domain {452-472}
exoplasmic loop {473-524}
transmembrane domain {525-545}
cytoplasmic domain {546-787}
Database Correlations
OMIM 601500
MORBIDMAP 601500
UniProt Q99835
PFAM correlations
Entrez Gene 6608
Kegg hsa:6608
References
UniProt :accession Q99835