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tumor suppressor protein MN1 (meningioma chromosome region 1 protein, MGCR1)

Expression: - ubiquitously expressed - highest levels in skeletal muscle Pathology: 1) a chromosomal translocation t(12;22)(p13;q11), MN1 with TEL is associated with acute myeloid leukemia (AML) 2) defects in MN1 may be a cause of meningiomas

General

phosphoprotein

Properties

SIZE: MW = 136 kD entity length = 1319 aa MOTIF: glutamine-rich region {295-309} MOTIF: glutamine residue (SEVERAL) glutamine-rich region {523-550} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S1080}

Database Correlations

OMIM correlations UniProt Q10571

References

  1. UniProt :accession Q10571
  2. Atlas of Genetics and Cytogenetics in Oncology and Haematology http://atlasgeneticsoncology.org/Genes/MN1.html