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MLL5-L complex
Function:
Structure:
- composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB & OGT
General
molecular complex
Properties
SUBUNITS: histone-lysine N-methyltransferase MLL5
COMPARTMENT: cell nucleus
MOTIF: Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 118-166
EFFECTOR-BOUND: Zn+2
SET domain {328-451}
coiled coil {559-615}
Ser phosphorylation site {S1405}
proline-rich region
SITE: 1433-1846
MOTIF: proline residue (SEVERAL)
serine/threonine protein kinase 38
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Thr phosphorylation site {T26}
S100B interaction {62-87}
MOTIF: Thr phosphorylation site {T74}
kinase domain
SITE: 89-382
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 95-103
ATP-binding site
NAME: ATP-binding site
SITE: 118-118
aspartate residue {D212}
Ser phosphorylation site {S281}
AGC-kinase C-terminal {383-455}
MOTIF: Thr phosphorylation site {T444}
STATE: active state
serine/threonine protein phosphatase PP1-alpha catalytic subunit
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Iron [Fe]-binding site
SITE: 64-64
Iron [Fe]-binding site
SITE: 66-66
Iron [Fe]-binding site
SITE: 92-92
MOTIF: manganese [Mn]-binding site
SITE: 92-92
manganese [Mn]-binding site
SITE: 124-124
histidine residue {H125}
manganese [Mn]-binding site
SITE: 173-173
manganese [Mn]-binding site
SITE: 248-248
Tyr phosphorylation site {Y306}
Thr phosphorylation site {T320}
STATE: active state
serine/threonine protein phosphatase PP1-beta catalytic subunit
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S41}
Ser phosphorylation site {S47}
Iron [Fe]-binding site
SITE: 63-63
Iron [Fe]-binding site
SITE: 65-65
Iron [Fe]-binding site
SITE: 91-91
MOTIF: manganese [Mn]-binding site
SITE: 91-91
manganese [Mn]-binding site
SITE: 123-123
histidine residue {H124}
manganese [Mn]-binding site
SITE: 172-172
manganese [Mn]-binding site
SITE: 247-247
Tyr phosphorylation site {Y306}
Thr phosphorylation site {T316}
STATE: active state
serine/threonine protein phosphatase PP1-gamma catalytic subunit
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Iron [Fe]-binding site
SITE: 64-64
Iron [Fe]-binding site
SITE: 66-66
Iron [Fe]-binding site
SITE: 92-92
MOTIF: manganese [Mn]-binding site
SITE: 92-92
manganese [Mn]-binding site
SITE: 124-124
histidine residue {H125}
manganese [Mn]-binding site
SITE: 173-173
manganese [Mn]-binding site
SITE: 248-248
cysteine residue {273}
Thr phosphorylation site {T307}
STATE: active state
host cell factor
COMPARTMENT: cell nucleus
MOTIF: kelch repeat {44-313} (5)
binding site
SITE: 610-722
FOR-BINDING-OF: paired amphipathic helix protein sin3a
binding site
SITE: 750-902
FOR-BINDING-OF: zinc finger & BTB domain-containing protein 17
binding site
SITE: 813-912
FOR-BINDING-OF: GABP2
HCF {1010-1035}
MOTIF: proteolytic site {1019-1020}
HCF {1072-1097}
MOTIF: proteolytic site {1081-1082}
HCF {1101-1126}
MOTIF: proteolytic site {1110-1111}
HCF {1158-1183}
HCF {1286-1311}
MOTIF: proteolytic site {1295-1296}
HCF {1314-1339}
MOTIF: proteolytic site {1323-1324}
HCF {1349-1374}
HCF {1414-1439}
MOTIF: proteolytic site {1423-1424}
actin, cytoplasmic 1
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyr phosphorylation site {Y53}
Tyr phosphorylation site {Y91}
Tyr phosphorylation site {Y166}
Tyr phosphorylation site {Y169}
Tyr phosphorylation site {Y198}
Tyr phosphorylation site {Y218}
Tyr phosphorylation site {Y294}
Thr phosphorylation site {T318}
UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kD subunit
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S20}
tetratricopeptide repeat {21-54}
tetratricopeptide repeat {89-122}
tetratricopeptide repeat {123-156}
tetratricopeptide repeat {157-190}
tetratricopeptide repeat {191-224}
tetratricopeptide repeat {225-258}
tetratricopeptide repeat {259-292}
tetratricopeptide repeat {293-326}
tetratricopeptide repeat {327-360}
tetratricopeptide repeat {361-394}
tetratricopeptide repeat {395-428}
tetratricopeptide repeat {429-462}
tetratricopeptide repeat {463-473}
nuclear translocation signal {487-503}
References
UniProt :accession O15294
Components
actin, cytoplasmic 1; beta-actin (ACTB)
histone-lysine N-methyltransferase MLL5 (myeloid/lymphoid or mixed-lineage leukemia protein 5, lysine N-methyltransferase 2E, MLL5, KMT2E)
host cell factor; HCF; HCF-1; C1 factor; VP16 accessory protein; VCAF; CFF (HCFC1, HCF1)
serine/threonine protein kinase 38; NDR1 protein kinase; nuclear Dbf2-related kinase 1 (STK38, NDR1)
serine/threonine protein phosphatase PP1-alpha catalytic subunit; PP-1A (PPP1CA, PPP1A)
serine/threonine protein phosphatase PP1-beta catalytic subunit (PPP1CB)
serine/threonine protein phosphatase PP1-gamma catalytic subunit; PP-1G; protein phosphatase 1C catalytic subunit (PPP1CC)
UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kD subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kD subunit (OGT)