histone-lysine N-methyltransferase MLL5 (myeloid/lymphoid or mixed-lineage leukemia protein 5, lysine N-methyltransferase 2E, MLL5, KMT2E)

Function: - histone methyltransferase - probably methylates Lys-4 of histone H3 - histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation (putative) - overexpression inhibits cell cycle progression S-adenosyl-L-methionine + histone L-lysine S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine Structure: - belongs to the histone-lysine methyltransferase family, TRX/MLL subfamily - contains 1 PHD-type Zn⁺² finger - contains 1 SET domain Compartment: - nucleus speckle - absent from the nucleolus Alternative splicing: named isoforms=7 Expression: - widely expressed in both adult & fetal tissues - highest levels of expression observed in fetal thymus & kidney & in adult hematopoietic tissues, jejunum & cerebellum

General

histone N-methyltransferase phosphoprotein zinc finger protein

Properties

SIZE: entity length = 1858 aa MW = 205 kD COMPARTMENT: cell nucleus MOTIF: Zn finger PHD-type NAME: Zn finger PHD-type SITE: 118-166 EFFECTOR-BOUND: Zn+2 SET domain {328-451} coiled coil {559-615} Ser phosphorylation site {S1405} proline-rich region SITE: 1433-1846 MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM 608444 UniProt Q8IZD2 PFAM correlations Kegg hsa:5590 ENZYME 2.1.1.43

References

UniProt :accession Q8IZD2