myosin regulatory light polypeptide 9; myosin regulatory light chain 9; myosin regulatory light chain MRLC1; myosin regulatory light chain 2, smooth muscle isoform; myosin RLC; MLC-2C; LC20 (MYL9, MLC2, MRLC1, MYRL2)

Function: - myosin regulatory light chain - role in regulation of both smooth muscle & nonmuscle cell contractile activity via its phosphorylation - implicated in cytokinesis, receptor capping, & cell locomotion - phosphorylation increases the actin-activated myosin ATPase activity, thus regulates the contractile activity - required to generate the driving force in the migration of cells, but not necessary for localization of myosin-2 at the leading edge (putative) - binds Ca⁺² Structure: contains 3 EF-hand domains Expression: - smooth muscle tissues & in some, but not all, nonmuscle cells

Properties

SIZE: entity length = 172 aa MW = 20 kD MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Thr phosphorylation site {T19} Ser phosphorylation site {S20} EF hand SITE: 29-64 MOTIF: Ser phosphorylation site {S29} Ca+2-binding site SITE: 42-53 EF hand SITE: 98-133 EF hand SITE: 134-169 MOTIF: Thr phosphorylation site {T135}

Database Correlations

OMIM 609905 UniProt P24844 Pfam PF00036 Entrez Gene 10398 Kegg hsa:10398

References

UniProt :accession P24844