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muskelin (MKLN1)
Function:
- acts as a mediator of cell spreading & cytoskeletal responses to the extracellular matrix component thrombospondin 1
- interacts with the C-terminal tail of the prostaglandin EP3 receptor alpha isoform (putative)
- interacts with RANBP9 part of a complex consisting of RANBP9, MKLN1 & C20orf11
Structure:
- contains 1 CTLH domain
- contains 6 kelch repeats
- contains 1 LisH domain
Compartment: cytoplasm (putative)
Alternative splicing: named isoforms=2
General
other protein
Properties
SIZE: entity length = 735 aa
MW = 85 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
LisH {172-204}
CTLH {206-258}
kelch repeat {284-330}
kelch repeat {339-391}
kelch repeat {408-458}
kelch repeat {469-515}
kelch repeat {526-578}
kelch repeat {597-651}
Database Correlations
OMIM 605623
UniProt Q9UL63
PFAM correlations
Entrez Gene 4289
Kegg hsa:4289
References
UniProt :accession Q9UL63