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MBD2-interacting zinc finger protein; methyl-CpG-binding protein 2-interacting zinc finger protein (MIZF, HINFP)
Fucntion:
1) transcriptional repressor
2) binds to the consensus sequence 5'-CGGACGTT-3' & to the RB1 promoter
3) binds MBD2 & a histone deacetylase complex
Structure:
- contains 8 C2H2-type zinc fingers
Compartment: nucleus
Expression:
- ubiquitous
- highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta, liver
General
C2H2 type zinc finger protein
Properties
SIZE: MW = 60 kD
entity length = 517 aa
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 15-39
EFFECTOR-BOUND: Zn+2
glutamate-rich region {49-56}
MOTIF: glutamate residue (SEVERAL)
Zn finger C2H2-type
SITE: 129-153
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 169-193
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 229-251
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 255-278
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 284-306
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 312-337
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 345-368
EFFECTOR-BOUND: Zn+2
glutamate-rich region {440-444}
MOTIF: glutamate residue (SEVERAL)
Database Correlations
OMIM 607099
UniProt Q9BQA5
Pfam PF00096
References
UniProt :accession Q9BQA5