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mixed dementia
The coexistence of Alzheimer's disease & vascular dementia.
Pathology:
- dementia is more likely & likely to be more severe when vascular lesions coexist with the neurofibrillary tangles & amyloid plaques of Alzheimer's disease
Management:
1) cholinesterase inhibitors may be of modest clinical benefit
2) memantine may be of modest clinical benefit
3) cardiovascular risk control
a) hypertension
b) dyslipidemia
Related
Alzheimer's disease (AD)
vascular dementia
General
dementia; Alzheimer's disease & related dementias (ADRD)
References
Langa KM, Foster NL, Larson EB.
Mixed dementia: emerging concepts and therapeutic implications.
JAMA. 2004 Dec 15;292(23):2901-8. Review.
PMID: 15598922