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mitogen-activated protein kinase (MAP kinase) or microtubule-associated protein kinase

Function: - features of MAP kinases include a) activation by direct phosphorylation without a regulatory subunit b) dual phosphorylation by MAP kinase kinase (MEK) - usually two (one Tyr & one Thr) phosphorylation sites in the kinase activation loop [6] - may act downstream of p34cdc2 & may indirectly inactivate p34cdc2 [1] - MAP kinases are also activated by integrin cross-linking possibly via src [5]

Interactions

molecular events

Related

mitogen activated protein kinase kinase (MAP2K), MAPK/ERK kinase (MEK) ras signal transduction

Specific

c-jun NH2 terminal kinase, jun kinase (JNK) or stress-activated protein kinase (SAPK) extracellular signal regulated kinase [ERK] family protein human EGF receptor family-associated p40hera mitogen-activated protein kinase 15; MAP kinase 15; MAPK 15; extracellular signal-regulated kinase 7; ERK-7; extracellular signal-regulated kinase 8; ERK-8 (MAPK15, ERK7, ERK8) p38MAPK subfamily

General

proline-directed protein kinase

Figures/Diagrams

MAP kinase pathways

Properties

SIZE: MW = 42-44 kD COMPARTMENT: cytoplasm STATE: active state MOTIF: Thr-phosphate Tyr-phosphate kinase domain MOTIF: ATP-binding site NAME: ATP-binding site MISC-INFO: RECOGNITION-MOTIF :SEQUENCE TPR[T*]PPP

References

  1. Pelech SL, Sanghera JS. Mitogen-activated protein kinases: versatile transducers for cell signaling. Trends Biochem Sci. 1992 Jun;17(6):233-8. Review. PMID: 1323888 - Pelech SL, Sanghera JS. MAP kinases: charting the regulatory pathways. Science. 1992 Sep 4;257(5075):1355-6. No abstract available. PMID: 1382311
  2. Rossomando AJ, Payne DM, Weber MJ, Sturgill TW. Evidence that pp42, a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase. Proc Natl Acad Sci U S A. 1989 Sep;86(18):6940-3. PMID: 2550926
  3. Ballou LM, Luther H, Thomas G. MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways. Nature. 1991 Jan 24;349(6307):348-50. PMID: 1702881
  4. Payne DM, Rossomando AJ, Martino P, Erickson AK, Her JH, Shabanowitz J, Hunt DF, Weber MJ, Sturgill TW. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). EMBO J. 1991 Apr;10(4):885-92. PMID: 1849075
  5. Clark EA & Brugge JS Integrins and signal transduction pathways: the road taken. Science 268:233 1995 PMID: 7716514
  6. Pearson et al, Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocrine Reviews 22:153-83, 2001 PMID: 11294822