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mitochondrial antibody in serum

Indications: - primary biliary cirrhosis* * primary biliary cirrhosis also known as primary biliary cholangitis * laboratory values indicating need for anti-mitochondrial antibody - elevated markers of cholangitis: increased serum ALP, serum GGT - normal to near normal serum AST, serum ALT, serum bilirubin Clinical significance: 1) autoantibody associated with primary biliary cirrhosis directed at the mitochondrial M2 antigen 2) high titers (1:160) are diagnostic of primary biliary cirrhosis a) antibodies preceed signs/symptoms b) occur in adults NOT children, with rare exceptions c) reacts with epitope in pyrvatate dehydrogenase-E2 containing lipoic acid 3) lower titers associated with a) chronic active hepatitis b) alcoholic hepatitis c) viral hepatitis Specimen: - serum: store at -20 degrees C

Related

primary biliary cirrhosis; primary biliary cholangitis

Specific

mitochondrial antibody in serum pattern mitochondrial antibody in serum qualitative mitochondrial antibody in serum quantitative mitochondrial IgG in serum mitochondrial M2 antibody in serum mitochondrial M4 antibody in serum mitochondrial M5 antibody in serum mitochondrial M9 antibody in serum

General

mitochondrial antibody in body fluid

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, 19. American College of Physicians, Philadelphia 1998, 2021
  2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995