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anti-mitochondrial antibody

Etiology: 1) autoantibody associated with primary biliary cirrhosis* directed at the mitochondrial M2 antigen 2) high titers (1:160) are diagnostic of primary biliary cirrhosis* a) antibodies preceed signs/symptoms b) occur in adults NOT children, with rare exceptions c) reacts with epitope in pyrvatate dehydrogenase-E2 containing lipoic acid 3) lower titers associated with a) chronic active hepatitis b) alcoholic hepatitis c) viral hepatitis * primary biliary cirrhosis also known as primary biliary cholangitis Laboratory: - mitochondrial antibody in body fluid * laboratory values indicating need for anti-mitochondrial antibody - elevated markers of cholangitis: increased serum ALP, serum GGT - normal to near normal serum AST, serum ALT, serum bilirubin

Related

mitochondrial antibody in body fluid primary biliary cirrhosis; primary biliary cholangitis

Specific

anti-mitochondrial M2 antibody anti-mitochondrial M4 antibody anti-mitochondrial M5 antibody anti-mitochondrial M9 antibody

General

autoantibody

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, 19. American College of Physicians, Philadelphia 1998
  2. Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995