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miR-33

Pathology: - miR-33a & miR-33b inhibit production of HDL cholesterol - antisense oligonucleotides injected subcutaneously into monkeys increases HDL cholesterol & decreases serum triglycerides; effects persist for at least 12 weeks [1]

Properties

GENERAL: short interfering double-stranded RNA; antisense oligonucleotide (siRNA, microRNA, miRNA) FORM: miR-33

References

  1. Rayner KJ et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature 2011 Oct 20; 478:404 PMID: 22012398