miR-1

Pathology: - miR-1 is overproduced in ischemic cardiac muscle when overproduced in rat hearts, miR-1 induces ectopy slows conduction & depolarizes the cytoplasmic membrane by post-transcriptionally repressing: KCNJ2 (encodes the K⁺ channel subunit Kir2.1) & GJA1 (which encodes connexin 43)

Properties

GENERAL: short interfering double-stranded RNA; antisense oligonucleotide (siRNA, microRNA, miRNA) FORM: miR-1

References

- Yang B, Lin H, Xiao J, Lu Y, Luo X, Li B, Zhang Y, Xu C, Bai Y, Wang H, Chen G, Wang Z. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med. 2007 Apr;13(4):486-491. Epub 2007 Apr 1. PMID: 17401374