minichromosome maintenance (Mcm) complex

Function: - controls onset of S phase - contains helicases that unwind DNA - in association with origin of replication complex & Cdc6 & Cdt1 forms pre-replication complex

General

helicase (DNA unwinding protein, DNA untwisting protein) molecular complex

Properties

COMPARTMENT: cell nucleus MOTIF: DNA-binding motif active site MOTIF: P-loop FOR-BINDING-OF: adenosine triphosphate SUBUNITS: DNA replication licensing factor MCM3 MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S160} MCM {295-502} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 345-352 Ser phosphorylation site {S535} Ser phosphorylation site {S668} Ser phosphorylation site {S672} Thr phosphorylation site {T674} Ser phosphorylation site {S681} Ser phosphorylation site {S704} Tyr phosphorylation site {Y708} Ser phosphorylation site {S711} Thr phosphorylation site {T713} Thr phosphorylation site {T722} Thr phosphorylation site {T725} Ser phosphorylation site {S728} Ser phosphorylation site {S734} DNA replication licensing factor MCM2 MOTIF: MYST2 interaction {2-257} acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S4} Ser phosphorylation site {S5} Ser phosphorylation site {S7} Ser phosphorylation site {S12} Ser phosphorylation site {S13} Thr phosphorylation site {T25} Ser phosphorylation site {S26} Ser phosphorylation site {S27} Ser phosphorylation site {S32} Thr phosphorylation site {T39} Ser phosphorylation site {S40} Ser phosphorylation site {S41} Ser phosphorylation site {S53} Thr phosphorylation site {T59} Thr phosphorylation site {T106} Ser phosphorylation site {S108} Ser phosphorylation site {S139} Zn finger C4-type SITE: 329-355 EFFECTOR-BOUND: Zn+2 Ser phosphorylation site {S381} MCM {473-679} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 523-530 DNA replication licensing factor MCM7 MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S121} MCM {332-538} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 381-388 Ser phosphorylation site {S500} RAD17 interaction {521-564} MOTIF: Ser phosphorylation site {S549} ATRIP interaction {577-719} DNA replication licensing factor MCM6 MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S271} MCM {346-553} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 396-403 Ser phosphorylation site {S762} Thr phosphorylation site {T791} DNA replication licensing factor MCM4 MOTIF: Thr phosphorylation site {T19} Ser phosphorylation site {S26} Ser phosphorylation site {S31} Ser phosphorylation site {S32} Ser phosphorylation site {S34} Ser phosphorylation site {S54} Thr phosphorylation site {T102} Ser phosphorylation site {S105} Thr phosphorylation site {T110} Ser phosphorylation site {S120} Ser phosphorylation site {S131} Ser phosphorylation site {S142} Ser phosphorylation site {S145} Ser phosphorylation site {S326} MCM {458-667} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 510-517 DNA replication licensing factor MCM5 MOTIF: MCM {331-537} MOTIF: ATP-binding site NAME: ATP-binding site SITE: 381-388

Components

DNA replication licensing factor MCM2; minichromosome maintenance protein 2 homolog; nuclear protein BM28 (MCM2 BM28 CCNL1 CDCL1 KIAA0030) DNA replication licensing factor MCM3; DNA polymerase alpha holoenzyme-associated protein P1; RLF subunit beta; P102 protein; P1-MCM3 (MCM3) DNA replication licensing factor MCM4; CDC21 homolog; P1-CDC21 (MCM4 CDC21) DNA replication licensing factor MCM5; CDC46 homolog; P1-CDC46 (MCM5, CDC46) DNA replication licensing factor MCM6; p105MCM (MCM6) DNA replication licensing factor MCM7; CDC47 homolog; P1.1-MCM3 (MCM7 CDC47 MCM2)