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mineral oil (Kondremul)
Tradename: Kondremul.
Indications:
- relief of constipation
- bowel preparation
- ophthalmic
- dry eyes, Sjogren's syndrome
Contraindications:
pregnancy-category C
safety in lactation ?
Dosage: 5-45 mL PO QHS, 5-15 mL dose for child.
Pharmacokinetics:
1) absorption from the GI tract is minimal
2) 30-60% of the emulsion may be absorbed from the intestine, especially in combination with docusate (Colace)
3) bowel relief generally occurs within 6-8 hours
4) elimination: Not absorbed.
Adverse effects:
1) with long-term therapy can decrease absorption of fat-soluble vitamins
2) aspiration in patients at risk
3) may cause mineral oil leaking from rectum
Drug interactions:
- docusate in combination causes increased systemic absorption of mineral oil & may lead to fatty liver
Mechanism of action: lubricant laxative
General
laxative
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Drug Information & Medication Formulary, Veterans Affairs,
Central California Health Care System, 1st ed., Ravnan et al
eds, 1998
- Deprecated Reference
Component-of
carboxymethylcellulose/mineral oil/white petrolatum
ceresin wax/mineral oil/petrolatum (Absorbase)
glycerol/lidocaine/mineral oil/petrolatum/phenylephrine
lanolin/mineral oil/white petrolatum
lidocaine/mineral oil/petrolatum/phenylephrine
magnesium hydroxide/mineral oil
mineral oil/petrolatum
mineral oil/phenylephrine/shark liver oil/white petrolatum
mineral oil/phenylephrine/white petrolatum
mineral oil/pramoxine/witch hazel/zinc oxide
mineral oil/white petrolatum
ceresin wax/mineral oil/petrolatum (Absorbase)