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Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet

A hybrid of the low-sodium DASH diet & the Mediterranean diet. Clinical significance: - associated with slower cognitive decline in healthy older people* - may help prevent cognitive decline after stroke - may lower risk of Alzheimer's disease [4,5] - may delay onset of Parkinson's disease [6] - associated with better cognitive function independent of common brain pathology - MIND diet may contribute to cognitive resilience in the elderly [7] - adherence to a MIND diet is associated with a reduced risk of dementia in middle-age & older adults [8] - MIND diet did not affect cognitive decline (within 3 years) in adults > 65 years with a family history of dementia [9] - adherence to a MIND diet associated with larger volumes of thalamus, putamen, pallidum, hippocampus, & nucleus accumbens & lower white matter hyperintensities [10] - observed regardless of genetic predispositions of Alzheimer's disease - MIND diet & Mediterranean diet associated with less post-mortem Alzheimer's disease pathology, mainly beta-amyloid [11] - higher green leafy vegetables associated with less Alzheimer's disease pathology [11] - MIND diet associated with slower cognitive decline in older adults (Black or White) - may vary with lifestyle & vascular factors [12] * opinion citing reference [9] disagrees, reference [9] may set standard of care [Jan 2023] Management: - low-salt diet - focus on fruits, vegetables, whole grains, lean protein

General

Mediterranean diet Dietary Approaches to Stop Hypertension (DASH) diet

References

  1. Anderson P MIND Diet May Slow Cognitive Decline in Stroke Survivors. Medscape - Jan 30, 2018. https://www.medscape.com/viewarticle/891957
  2. Brooks M Hybrid 'MIND' Diet Keeps Aging Brain Sharp Medscape - Aug 10, 2015. https://www.medscape.com/viewarticle/849251
  3. Morris MC, Tangney CC, Wang Y et al MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015 Sep;11(9):1015-22. Epub 2015 Jun 15. PMID: 26086182 Free PMC Article http://www.alzheimersanddementia.com/article/S1552-5260(15)00194-6/abstract
  4. Jacobs AR Can the MIND Diet Reduce Alzheimer's Risk? Medscape. March 8, 2016 http://www.medscape.com/viewarticle/858958
  5. van den Brink AC, Brouwer-Brolsma EM, Berendsen AAM, van de Rest O. The Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diets Are Associated with Less Cognitive Decline and a Lower Risk of Alzheimer's Disease - A Review. Adv Nutr. 2019 Nov 1;10(6):1040-1065. PMID: 31209456 Free PMC article.
  6. Metcalfe-Roach A, Yu AC, Golz E et al MIND and Mediterranean Diets Associated with Later Onset of Parkinson's Disease. Movement Disorders. 2021. Jan 6 PMID: 33404118 https://onlinelibrary.wiley.com/doi/10.1002/mds.28464
  7. Brooks M MIND Diet Preserves Cognition Even in the Presence of Alzheimer's Pathology. Medscape. September 28, 2021 https://www.medscape.com/viewarticle/959891 - Dhana K James BD, Agarwal P et al MIND Diet, Common Brain Pathologies, and Cognition in Community-Dwelling Older Adults. J Alzheimers Dis. 2021;83(2):683-692 PMID: 34334393 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210107
  8. George J Dementia Risk and Diet Investigated. Analysis probes multiple studies about the MIND diet approach. MedPage Today May 3, 2023 https://www.medpagetoday.com/neurology/dementia/104321 - Chen H, Dhana K, Huang Y et al Association of the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet With the Risk of Dementia. JAMA Psychiatry. Published online May 3, 2023 PMID: 37133875 https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2804268
  9. Harris E MIND Diet No Better Than Control for Adults at Risk of Dementia. JAMA. Published online July 26, 2023. https://jamanetwork.com/journals/jama/fullarticle/2807897 - Barnes LL et al. Trial of the MIND diet for prevention of cognitive decline in older persons. N Engl J Med 2023 Jul 18 PMID: 37466280 https://www.nejm.org/doi/10.1056/NEJMoa2302368
  10. George J MIND Diet in Midlife Tied to Higher Subcortical Brain Region Volumes. MedPage Today November 9, 2023 https://www.medpagetoday.com/neurology/dementia/107255 - Chen H, Dunk MM, Wang B et al Associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay diet with brain structural markers and their changes. Alzheimer's & Dementia. 2023. Nov 6. PMID: 37932860 https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.13521
  11. Agarwal P, Leurgans SE, Agrawal S et al Association of Mediterranean-DASH Intervention for Neurodegenerative Delay and Mediterranean Diets With Alzheimer Disease Pathology. Neurology. 2023 May 30;100(22):e2259-e2268. Epub 2023 Mar 8. PMID: 36889921
  12. Agarwal P, Barnes LL, Dhana K et al Association of MIND diet with cognitive decline among Black and White older adults. Alzheimers Dement. 2024 Oct 16. PMID: 39410855