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Fisher syndrome (Miller-Fisher syndrome, anti GQ1b antibody syndrome)
The most common variant of Guillain-Barre syndrome, accounting for 5% of all cases. (also see NINDS Miller Fisher Syndrome Information Page)
Etiology:
- may be associated with infections, autoimmune & neoplastic disorders
Pathology:
- neuromuscular transmission defects in association with anti GQ1b IgG antibody
Clinical manifestations:
1) ophthalmoplegia
2) ataxia
3) areflexia
4) little weakness
Laboratory:
- anti GQ1b IgG antibody titer (generally elevated)
Management:
- mostly, acute, self-limiting syndrome
- anecdotal evidence of benefit with immunotherapy
General
Guillain-Barre syndrome (GBS)
References
- Saunders Manual of Medical Practice, Rakel (ed),
WB Saunders, Philadelphia, 1996, pg 1073
- Lo YL,
Clinical and immunological spectrum of the Miller Fisher syndrome.
Muscle Nerve 2007, 36:615
PMID: 17657801
- NINDS Miller Fisher Syndrome Information Page
https://www.ninds.nih.gov/Disorders/All-Disorders/Miller-Fisher-Syndrome-Information-Page