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mild-persistent asthma
Clinical manifestations:
1) beta-gonist use > 2 days/week, but < daily
2) asthma-related night-time wakenings > 2 nights/month, but < 1 night/week
Special laboratory:
- spirometry
Management:
1) inhaled glucocorticoid
a) budesonide MDI BID or equivalent
b) more symptom-free days
2) oral leukotriene receptor antagonist
a) zafirlukast
b) may be of little value
3) inhaled beta-adrenergic agonist PRN
- albuterol MDI
General
asthma
References
- Journal Watch 25(10):84, 2005
Boushey HA, Sorkness CA, King TS, Sullivan SD, Fahy JV,
Lazarus SC, Chinchilli VM, Craig TJ, Dimango EA, Deykin A,
Fagan JK, Fish JE, Ford JG, Kraft M, Lemanske RF Jr, Leone FT,
Martin RJ, Mauger EA, Pesola GR, Peters SP, Rollings NJ,
Szefler SJ, Wechsler ME, Israel E; National Heart, Lung, and
Blood Institute's Asthma Clinical Research Network.
Daily versus as-needed corticosteroids for mild persistent
asthma.
N Engl J Med. 2005 Apr 14;352(15):1519-28.
PMID: 15829533
- http://www.nhlbi.nih.gov/health/prof/lung/asthma/practgde/practgde.pdf