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miglitol (Glyset)
Tradename: Glyset.
Indications: diabetes mellitus type-2
Dosage:
1) start 25 mg PO QD with food
2) maintenance: 50-100 mg TID
Tabs: 25, 50, 100 mg.
Monitor:
1) post-prandial glucose
2) hemoglobin A1c (HgbA1c)
3) no need to monitor liver function
Mechanism of action:
1) inhibits alpha-glucosidase
2) delays breakdown of complex carbohydrates in the intestine
3) reduces HgbA1c levels in patients with type-2 diabetes
Interactions
drug interactions
drug adverse effects of hypoglycemic agents
General
alpha glucosidase inhibitor
Properties
INHIBITS: maltase
MISC-INFO: elimination route KIDNEY
pregnancy-category B
safety in lactation -
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Kaiser Permanente Northern California Regional Drug Alert