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mesoderm induction early response protein 1 (Mi-er1, hmi-er1, early response 1, Er1, MIER1, KIAA1610)
Function:
- transcriptional repressor of a number of genes including Sp1 target genes
- interacts with HDAC1
Structure:
- contains 1 ELM2 domain
- contains 1 SANT domain
Compartment:
- isoforms 1,2,3: nucleus
- isoforms 4,5,6: cytoplasm
Expression:
- ubiquitously expressed, but at very low levels
- consistent level of expression are observed in heart, testis, thyroid, ovary & adrenal gland
Pathology:
- transcripts are up-regulated in breast carcinoma cell lines breast cancer
General
phosphoprotein
transcriptional silencer (transcriptional repressor)
Properties
SIZE: MW = 61 kD
entity length = 536 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: glutamate-rich region {60-205}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S146}
HDAC1 interaction {179-283}
MOTIF: Ser phosphorylation site {S190}
ELM2 {204-302}
SANT {307-359}
Ser phosphorylation site {S401}
Thr phosphorylation site {T405}
Ser phosphorylation site {S407}
Ser phosphorylation site {S507}
Ser phosphorylation site {S512}
Database Correlations
UniProt Q8N108
PFAM correlations
References
UniProt :accession Q8N108